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Nandrolone (Deca Durabolin) Nandrolone is one of the most commonly used steroids for muscle growthand hypertrophy in anabolic steroid abusers and patients abusing glucocorticoids and estrogen. Nandrolone is a synthetic hormone that is a precurser to endogenous and exogenous steroid metabolism. It has been administered orally as various dosages in human therapeutic use. It binds at the CB2 receptor, which is a central target of the drug CB1 receptor in humans. It has been demonstrated that Nandrolone acts at the CB2 receptor to suppress and reduce the expression of anabolic steroid receptors.Nandrolone can cause the following adverse effects in animal models:It is also been found that Nandrolone impairs the ability of human skeletal muscle to utilize nutrients. It is thought that Nandrolone acts as a substrate to increase the rate at which it is converted to cortisol in the human body. This is thought to occur when Nandrolone is also metabolized by the hepatic enzyme CYP3A4. In mice the liver of Nandrolone treated rats display higher concentrations of circulating cortisol. This is due to increased concentrations of serum cortisol when compared to controls. These mice also failed to exhibit increases in glucose uptake after exercise due to increased levels of Nandrolone in the blood. While the mechanism(s) behind these differences is unclear, it is speculated that high levels of glucocorticoid metabolites (including Nandrolone) increases the rates of metabolism and conversion of fatty acids into glucose; this increases the availability of circulating glucose in the liver and results in increased rates of exercise (e.g. from exercise training).Nandrolone also appears to modify insulin and glucagon in mice. This may be due to differences in glucose tolerance, which causes both effects.Nandrolone is not regulated or regulated using the CB1 receptor, meaning that oral doses of it cannot be used and is not metabolized through the CYP3A4 or any other glucocorticoid or exogenous metabolite metabolism in a similar fashion to endogenous steroids. Nandrolone is thus likely an exogenous metabolite of endogenous steroids in humans because it can be converted in vivo to glucocorticoids in the liver. This means that it can be used or abused without the adverse effects associated with endogenous steroids.One of the most commonly found side effects of Nandrolone in a variety of animal models is hyperhidrosis, a condition where a person findsSimilar articles: