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In most cases in which the anabolic properties of AASs are desired, an increased ingestion of protein and calories must accompany their use. The addition of protein in such a context may cause insulin production and the subsequent hyperinsulinemia of anabolic hormones. In summary, although there may be a case for protein alone in the diet for some anabolic goals, anabolic stimulation from such a protein supplement must be accompanied by an increased caloric intake. The ingestion of either a combination of dietary protein and a carbohydrate-induced increase in glycemic index (i.e., containing a relatively large proportion of glucose in a small volume of digestible carbohydrate) can increase insulin production or induce hyperinsulinemia, whereas either of these mechanisms can be utilized without increasing caloric intake. The relative contributions of each mechanism will depend on the circumstances: a higher contribution of insulin-mediated insulin production in a hypertensive state to stimulate anabolism than in anemic states, or insulin-mediated hyperinsulinemia as anabolic stimulation to induce anabolic hormone secretion. The authors' responsibilities were as follows—R.E., M.K., E.J., and H.P. conducted the study; R.E. and M.K. performed the statistical analyses; R.E. and M.K. analyzed data and wrote the manuscript; and all authors contributed to the study design. REFERENCES 1999 ) Protein and IGF-I metabolism in male and female rats. Endocrinology 143 , 1643 –1648. Pimentel, C.A., and P.Z. Lefevre) protein and IGF-I metabolism in male and female rats.–1648. 1988 ) Animal model for the development of growth factors and hormone resistance. J. Exp. Clin. Endocrinol Metab. 67 , 691 –695. Pimentel, C.A., R.J. DeYoung, Z.R. Wootten, and W.M. Johnson) animal model for the development of growth factors and hormone resistance.–695. 1971 ) Studies of growth hormone action in man. Endocrine 3 , 633 –639. Pimentel, C.A., R.J. DeYoung, and B.W. Riggs) Studies of growth hormone action in man.–639. 1986 ) Effect of feeding amino acid-meal meals containing either carbohydrate or protein on amino acid retention, blood urea nitrogen and plasma amino acid concentration. J. Nutr. 130 , 1123 –1124. Schleicher, C.E., M.L. B Related Article:
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